Psma Expression Prostate Cancer
The decrease in PSMA immunoreactivity noted in advanced prostate cancer suggests that expression of this molecule may be linked to the degree of tumor differentia-. PSMA-PET-CT enables measuring molecular expression of prostate-specific membrane antigen PSMA in vivo which is the target molecule of 177 Lu-PSMA-617 Lu-PSMA therapy.
Ijms Free Full Text Enzalutamide Enhances Psma Expression Of Psma Low Prostate Cancer Html
Prostate-specific membrane antigen PSMA also known as glutamate carboxypeptidase II is a zinc metalloenzyme encoded by FOLH1 that resides in the cellular membrane As noted by its name PSMA is highly expressed in prostate cancer cells as high as 100 to 1000 times compared with in normal prostate cells and even higher in advanced stages and castration-resistant prostate cancers.
Psma expression prostate cancer. Prostate-specific membrane antigen PSMA is a type II integral membrane glycoprotein that was initially characterized by the monoclonal antibody mAb 7E11. PSMA is a largely prostate-specific transmembrane protein expressed 100- to 1000-fold higher in prostatic adenocarcinoma than in the benign prostate. PSMA expression is highly homogenous in primary prostate cancer.
Prostate-specific membrane antigen PSMA-directed radioligand therapy RLT prolongs overall survival in men with metastatic castration-resistant prostate cancer mCRPC. But another protein prostate-specific membrane antigen PSMA is also linked to prostate cancer. The overexpression of PSMA in 80 of patients with prostate cancer makes it an attractive target and a key phenotypic biomarker in advanced prostate cancer.
In RPE specimens PSMA overexpression has already been linked to an unfavorable biochemical recurrence free survival rate 16 18. PSMA expression was correlated with GS in both sample types biopsies P 00001 and prostatectomy samples P 0007. 23 Small molecules antibodies and antibody fragments that target PSMA have been.
In prostate biopsy and RPE specimen PSMA expression also significantly correlates with Gleason Score 18 implying a potential prognostic value for PSMA in prostate biopsy as well. 1 PSMA has been used as a phenotypic biomarker with positron emission tomography PET imaging approaches. We explored the effect of androgen receptor blockade with enzalutamide on PSMA expression.
Additionally up to 95 of prostate cancer cells express PSMA according to Jeremie Calais MD MSc an assistant professor of nuclear medicine and theranostics and director of the Theranostics Clinical Research Program at the University of California Los Angeles. PSMA seems to be expressed in other cancers conventional renal cell transitional cell of the bladder. 1 Of importance PSMA expression is increased on androgen deprivation and is highest in high-grade and castration-resistant prostate cancer CRPC.
However men with low PSMA expression are excluded from RLT. Studies have consistently demonstrated prostate-specific membrane antigen PSMA expression in all types of prostate. Prostate-specific antigen PSA can be an indicator of prostate cancer and is easily detected and measured with a blood test.
We observed lower PSMA expression in Gleason pattern 3 than Gleason pattern. However the correlation of PSMA expression and overall survival OS in patients treated with Lu-PSMA therapy is currently unclear. Extraprostatic PSMA expression appears to be highly restricted.
Nevertheless its diverse anatomical distribution implies a broader functional significance than previously suspected. PSMA is a transmembrane protein that is anchored in the cell membrane of prostate cancer epithelial cells. PSMA is not only widely expressed in prostate cancer cells but is also present in NECs of non-prostate tumors such as non-small cell lung cancer NSCLC 1518.
While 177Lu-PSMA-617 has recently shown benefit in metastatic castration resistant prostate cancer other treatment approaches including androgen receptor pathway inhibitors ARPI have been utilized in this disease space and metastatic hormone-sensitive prostate cancer mHSPC for many years. Especially with regard to coexistence of high and low PSMA expressing. Recent evidence suggests that PSMA is also expressed in tumor-associated neovasculature.
Unlike other tumor neovasculature targets PSMA is expressed specifically in tumor NECs and is not expressed in the endothelial cells of normal tissues. PSMA is highly expressed in prostate secretory-acinar epithelium and prostate cancer as well as in several extraprostatic tissues. Given the high frequency and high homogeneity of PSMA expression in prostate cancer we conclude that increased PSMA expression may occur early in prostate cancer development.
PSMA is present at a low level even in normal prostate tissue but the amount is markedly higher in prostate cancer cells. Reverse transcriptase polymerase chain reaction of serum PSMA is not.
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